Vitamin D vs St. John's Wort

for mood

Stronger evidence: St. John's Wort

Stronger effect: St. John's Wort

Safety: St. John's Wort has the more serious interaction profile (minor vs contraindicated).

For mood, St. John's Wort has the stronger evidence grade.

grade C low certainty

small mood benefit, mostly in people who are deficient

grade B moderate certainty

effective for mild-to-moderate depression in trials

300 mg ×3/day, adults, mild-to-moderate depression

sources: PMID:00000005 · PMID:00000009