St. John's Wort
settled St. John's Wort — established for mild depression; interaction-heavy
⚠ Safety in context
- contraindicatedwith SSRI: St. John's Wort with an SSRI risks serotonin syndrome — do not combine.
- moderatewith Ashwagandha: Two serotonergic/sedating botanicals together may have additive effects.
Evidence by outcome
moodgrade Bmoderate certainty— effective for mild-to-moderate depression in trials
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sources: PMID:00000009