Melatonin vs 5-HTP

for sleep

Stronger evidence: Melatonin

Stronger effect: Melatonin

Safety: 5-HTP has the more serious interaction profile (uncertain vs serious).

For sleep, Melatonin has the stronger evidence grade.

grade B moderate certainty

reduces time to fall asleep; best for circadian timing

0.5–3 mg

grade C low certainty

limited evidence for sleep; serotonergic, so caution with antidepressants

sources: PMID:00000006 · PMID:00000036