5-HTP vs Ashwagandha

for sleep

Stronger evidence: tie

Stronger effect: tie

Safety: 5-HTP has the more serious interaction profile (serious vs moderate).

For sleep, the two are evidence-matched; the difference is in effect and safety.

grade C low certainty

limited evidence for sleep; serotonergic, so caution with antidepressants

grade C low certainty

small, early-stage effect on sleep

sources: PMID:00000036 · PMID:00000002