Ashwagandha
surging ashwagandha — attention is ahead of the evidence
⚠ Safety in context
- moderatewith SSRI: Ashwagandha with an SSRI may carry additive sedative/serotonergic risk; evidence is limited.
- moderatewith St. John's Wort: Two serotonergic/sedating botanicals together may have additive effects.
Evidence by outcome
sleepgrade Clow certainty— small, early-stage effect on sleep
stressgrade Clow certainty— small reduction in perceived stress in short trials
People say · Evidence shows
“Ashwagandha balances cortisol”
aheadlargemechanistic speculation
What changed
- untested → C (2026-02-10) — Additional small RCTs moved stress from untested to a weak, gradeable effect.
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sources: PMID:00000002 · PMID:00000012