Creatine vs Lion's Mane
for cognition
Stronger evidence: Creatine
Stronger effect: Creatine
Safety: No notable interactions recorded for either.
For cognition, Creatine has the stronger evidence grade.
Creatine
grade B moderate certainty
benefit to cognition, clearest under sleep deprivation or stress
5 g/day
Lion's Mane
grade C low certainty
early, small studies suggest a modest cognitive effect
~1 g/day, adults
sources: PMID:00000004 · PMID:00000010