Caffeine vs Omega-3

for cognition

Stronger evidence: Caffeine

Stronger effect: unknown

Safety: Omega-3 has the more serious interaction profile (minor vs serious).

For cognition, Caffeine has the stronger evidence grade.

grade A high certainty

reliably improves alertness, reaction time, and vigilance

40–200 mg, adults

not well studied very-low certainty

not adequately studied for cognition in healthy adults

sources: PMID:00000020